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Article

Virulence during Newcastle Disease Viruses Cross Species Adaptation.

Viruses - 15 Jan 2021

Afonso Claudio L

Abstract excerpt

The hypothesis that host adaptation in virulent Newcastle disease viruses (NDV) has been accompanied by virulence modulation is reviewed here. Historical records, experimental data, and phylogenetic analyses from available GenBank sequences suggest that currently circulating NDVs emerged in the 1920-1940's from low virulence viruses by mutation at the fusion protein cleavage site. These viruses later gave rise to...

Topics

Animals
Biological Evolution
Genetic Variation
Genome, Viral
Genomics
Host Adaptation
Host Specificity
Newcastle Disease
Newcastle disease virus
Phylogeny
Virulence
Virus Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33467506
DOI: 10.3390/v13010110
PMCID: PMC7830468

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