Spatially organized cellular communities shape functional tissue architecture in the pancreas

Abstract excerpt

Organ function depends on the precise spatial organization of cells across multiple scales, from individual cells to cellular communities that form specialized local niches and, ultimately, complex higher-order structures. While the identities of individual cell are increasingly well-defined, our understanding of how these diverse cell types are spatially distributed and communicate remains incomplete. In this stu...

Topics

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• Cancer Cells and Metastasis
• Diabetes and associated disorders
• Esophageal Cancer Research and Treatment
• IL-33, ST2, and ILC Pathways
• Liver physiology and pathology
• Pancreatic and Hepatic Oncology Research
• Pancreatic function and diabetes
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

f63c4b61-a4dd-5573-9ccf-24451c94f099

DOI

10.1101/2025.04.16.649169