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Integrative single-cell and spatial transcriptome analysis reveals heterogeneity of human liver progenitor cells

26 Feb 2025

Abstract excerpt

BACKGROUND: Liver progenitor cells (LPCs) with bipotential differentiation capacities are essential for restoring liver homeostasis and hepatocyte population after damage. However, the low proportion and shared markers with epithelial cells make studying LPC heterogeneity difficult, especially in humans. To address this gap, we explored over 259,400 human liver single cells across 4 conditions (fetal, healthy,...

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PMID: 40008906
DOI: 10.1097/hc9.0000000000000662

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