Article

EZH2-driven immune evasion at disease presentation defines a targetable high-risk subset of acute leukemia exemplified by t(16;21) FUS::ERG AML

2024-05-17

Abstract excerpt

<h4>ABSTRACT</h4> The past 25 years of clinical trials have produced few improvements in pediatric AML (pAML) outcomes. This is acutely evident in patients with t(16;21)(p11;q22), yielding FUS::ERG . Patients with FUS::ERG -positive AML relapse quickly and do not respond to transplantation. Major histocompatibility complex (MHC) class I & II receptors and costimulatory molecules are absent at diagnosis in FUS:...

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Literature Corpus work: f61d1328-913f-5443-9f1a-bd6478d6f8fb
DOI: 10.1101/2024.05.14.594150

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