Population genetics identifies challenges in analyzing rare variants.

Abstract excerpt

Geneticists have, for years, understood the nature of genome-wide association studies using common genomic variants. Recently, however, focus has shifted to the analysis of rare variants. This presents potential problems for researchers, as rare variants do not always behave in the same way common variants do, sometimes rendering decades of solid intuition moot. In this paper, we present examples of the...

Topics

• Genetic Variation
• Genetics, Population
• Genome, Human
• Genome-Wide Association Study
• High-Throughput Nucleotide Sequencing
• Humans