Article

Cholesterol metabolism is a potential therapeutic target in Duchenne Muscular Dystrophy

2020-12-02

Abstract excerpt

<h4>Background</h4> Duchenne Muscular Dystrophy (DMD) is a lethal muscle disease detected in approximately 1:5000 male births. DMD is caused by mutations in the DMD gene, encoding a critical protein that link the cytoskeleton and the extracellular matrix in skeletal and cardiac muscles. The primary consequence of the disrupted link between the extracellular matrix and the myofiber actin cytoskeleton is thought to...

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Literature Corpus work: 3313d25a-e243-5767-b177-834bfce74552
DOI: 10.1101/2020.12.01.405910

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