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Article

Cardiac remodeling in the mouse model of Marfan syndrome develops into two distinctive phenotypes.

American journal of physiology. Heart and circulatory physiology - 15 Jan 2016

Tae Hyun-Jin, Petrashevskaya Natalia, Marshall Shannon, Krawczyk Melissa, Talan Mark

Abstract excerpt

Marfan syndrome (MFS) is a systemic disorder of connective tissue caused by mutations in fibrillin-1. Cardiac dysfunction in MFS has not been characterized halting the development of therapies of cardiac complication in MFS. We aimed to study the age-dependent cardiac remodeling in the mouse model of MFS FbnC1039G+/- mouse [Marfan heterozygous (HT) mouse] and its association with valvular regurgitation. Marfan HT...

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Identifiers

PMID: 26566724
DOI: 10.1152/ajpheart.00354.2015
PMCID: PMC4747899

Genes

SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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