Article

Human SARS-CoV-2 challenge resolves local and systemic response dynamics

2023-04-25

Abstract excerpt

The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporally resolve abortive, transient and sustained infections in 16 seronegative individuals challenged with preAlpha-SARS-CoV-2. Our analyses revealed rapid changes in cell...

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Literature Corpus work: f5b16286-0e9b-585d-b7a1-4de74083957b
DOI: 10.1101/2023.04.13.23288227

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