Article

Respiration-Deficient Cells Require Pyruvate Carboxylase to Suppress Asparagine Auxotrophy

2026-08-13

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) compromise ETC activity and impair oxidative phosphorylation. Since eukaryotic cells contain multiple copies of mtDNA, the resulting phenotype depends on the proportion of mutant mitochondrial genomes (the heteroplasmy level). Using isogenic cell lines carrying similar mtDNA deletions, a linear decline in cellular respiration was observed as mitochondrial DNA heteroplasmy inc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f57f0d2c-2a39-55be-ba5e-9d721a102ee5
DOI: 10.64898/2026.08.12.744280

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Respiration-Deficient Cells Require Pyruvate Carboxylase to Suppress Asparagine AuxotrophyDOI 10.64898/2026.08.12.744280Read

Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cellsSemantic proximity Read

Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable VulnerabilitySemantic proximity Read

An Asp to Strike Out Cancer? Therapeutic Possibilities Arising from Aspartate’s Emerging Roles in Cell Proliferation and SurvivalSemantic proximity Read

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.Semantic proximity Read

Metabolism-focused CRISPR screen unveils Mitochondrial Pyruvate Carrier 1 as a critical driver for PARP inhibitor resistance in lung cancerSemantic proximity Read

Oncogene-Selective Sensitivity to Synchronous Cell Death following Modulation of the Amino Acid Nutrient Cystine.Semantic proximity Read

Metabolic Profile Of Leukemia Cells Influences Treatment Efficacy Of L‑AsparaginaseSemantic proximity Read

Metabolic profile of leukemia cells influences treatment efficacy of L-asparaginaseSemantic proximity Read

Mitochondrial aminoacyl-tRNA synthetases trigger unique compensatory mechanisms in neurons.Semantic proximity Read

Is Reliance on Mitochondrial Respiration a “Chink in the Armor” of Therapy-Resistant Cancer?Semantic proximity Read

Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.Semantic proximity Read

Glutamine-addiction in cisplatin resistant cancer cells is mediated by SLC7A11 and can be targeted with asparaginase therapySemantic proximity Read