Article

Chimeric Antigen Receptor T Cells Engineered to Secrete CD40 Agonist Antibodies Enhance Antitumor Efficacy

2020-11-06

Abstract excerpt

<title>Abstract</title> <p>BackgroundAlthough chimeric antigen receptor (CAR) T-cell therapy has made remarkable achievements against hematological malignancies, the efficacy of it against solid tumors has been limited. By being combined with immune checkpoint inhibitors, such as PD-1, PD-L1, or CTLA-4 antibodies, this therapy has been shown to be a promising strategy to enhance the antitumor efficacy of CAR-T ce...

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Literature Corpus work: f56fc7bc-50ea-5c19-ae4c-78ff49a78582
DOI: 10.21203/rs.3.rs-101499/v1

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