Article
Expansion and characterization of T cells transduced with a chimeric receptor against ovarian cancer.
Human gene therapy - 20 Nov 2000
Parker L L, Do M T, Westwood J A, Wunderlich J R, Dudley M E, Rosenberg S A, Hwu P
Abstract excerpt
Adoptive immunotherapy with genetically modified T lymphocytes is being utilized in clinical trials for the treatment of a broad range of diseases including cancer and HIV infection. To improve on these treatments, and to better understand their mechanisms of action, it is necessary to develop techniques to generate large numbers of cells and characterize the functional heterogeneity of the cells produced. In...
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