Article

Development of SARS-CoV-2 replicons for the ancestral virus and variant of concern Delta for antiviral screening

2022-10-12

Abstract excerpt

SARS-CoV-2 is the aetiologic agent of COVID-19 and the associated ongoing pandemic. As the pandemic has progressed, Variants of Concern (VOC) have emerged with lineage defining mutations. Using a SARS-CoV-2 reverse genetic system, based on transformation associated recombination in yeast, a series of replicons were produced for the ancestral Wuhan virus and the SARS-CoV-2 VOC Delta in which different combinations...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f543ebbd-8b0e-53ab-81b1-c2893bd726f8
DOI: 10.1101/2022.10.11.511804

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of SARS-CoV-2 replicons for the ancestral virus and variant of concern Delta for antiviral screeningDOI 10.1101/2022.10.11.511804Read

Replication and single-cycle delivery of SARS-CoV-2 replicons.Semantic proximity Read

Construction of a non-infectious SARS coronavirus replicon for application in drug screening and analysis of viral protein functionSemantic proximity Read

Subgenomic SARS-CoV-2 replicon and reporter replicon cell lines enable ultrahigh throughput antiviral screening and mechanistic studies with antivirals, viral mutations or host factors that affect COVID-19 replicationSemantic proximity Read

Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testingSemantic proximity Read

Reverse genetics systems for SARS‐CoV‐2Semantic proximity Read

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screeningSemantic proximity Read

Reverse genetics systems for SARS-CoV-2: Development and applicationsSemantic proximity Read

Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug ScreenSemantic proximity Read

Construction of a Noninfectious SARS-CoV-2 Replicon for Antiviral-Drug Testing and Gene Function StudiesSemantic proximity Read

Engineering a Reliable and Convenient SARS-CoV-2 Replicon System for Analysis of Viral RNA Synthesis and Screening of Antiviral Inhibitors.Semantic proximity Read

Cloning of a Passage-Free SARS-CoV-2 Genome and Mutagenesis Using Red RecombinationSemantic proximity Read

Scarless SARS-CoV-2 Genome Engineering and Variant AnalysisSemantic proximity Read