Article

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening

2021-12-25

Abstract excerpt

Experiments with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are limited by the need for biosafety level 3 (BSL3) conditions. A SARS-CoV-2 replicon system rather than an in vitro infection system is suitable for antiviral screening since it can be handled under BSL2 conditions and does not produce infectious particles. However, the reported replicon systems are cumbersome because of the need for...

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Literature Corpus work: 94eb8575-124a-55e3-afe3-e370c7247864
DOI: 10.1101/2021.12.23.474055

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