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Engineering a Reliable and Convenient SARS-CoV-2 Replicon System for Analysis of Viral RNA Synthesis and Screening of Antiviral Inhibitors.

mBio - 19 Jan 2021

Luo Yuewen, Yu Fei, Zhou Mo, Liu Yang, Xia Baijin, Zhang Xiantao, Liu Jun, Zhang Junsong, Du Yingying, Li Rong, Wu Liyang, Zhang Xu, Pan Ting, Guo Deyin, Peng Tao, Zhang Hui

Abstract excerpt

The etiologic agent of COVID-19 is highly contagious and has caused a severe global pandemic. Until now, there has been no simple and reliable system available in a lower-biosafety-grade laboratory for SARS-CoV-2 virologic research and inhibitor screening. In this study, we reported a replicon system which consists of four plasmids expressing the required segments of SARS-CoV-2. Our study revealed that the...

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Identifiers

PMID: 33468688
DOI: 10.1128/mBio.02754-20
PMCID: PMC7845634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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