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Integrative Transcriptomic and Network Analysis Reveals Small Open Reading Frames as Regulators of DNA Methylation-Linked Pathogenicity and Adaptability in <i>Leptospira interrogans</i>

2025-12-11

Abstract excerpt

Small open reading frames (sORFs) are increasingly recognized as crucial regulators in bacterial gene expression, yet their biological roles remain largely unexplored in pathogenic species. Here, we investigated the genome-wide regulatory landscape of sORFs in Leptospira interrogans serovar Manilae strain UP-MMC-NIID-LP using RNA-seq–based transcriptomic profiling integrated with weighted gene co-expression networ...

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Literature Corpus work
f534d248-0c14-5d0b-9dc6-752b8e9b22b8
DOI
10.64898/2025.12.08.692996
Open publication

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Integrative Transcriptomic and Network Analysis Reveals Small Open Reading Frames as Regulators of DNA Methylation-Linked Pathogenicity and Adaptability in <i>Leptospira interrogans</i>DOI 10.64898/2025.12.08.692996
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