Article

Integrative Transcriptomic and Network Analysis Reveals Small Open Reading Frames as Regulators of DNA Methylation-Linked Pathogenicity and Adaptability in Leptospira interrogans

2026-02-07

Abstract excerpt

<title>Abstract</title> Small open reading frames (sORFs) are increasingly recognized as crucial regulators in bacterial gene expression, yet their biological roles remain largely unexplored in pathogenic species. Here, we investigated the genome-wide regulatory landscape of sORFs in Leptospira interrogans serovar Manilae strain UP-MMC-NIID-LP using RNA-seq–based transcriptomic profiling integrated with weight...

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Literature Corpus work: 8389e7dc-a00c-5ee0-b1e6-6ab44d3e4276
DOI: 10.21203/rs.3.rs-8655069/v1

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