Article

Single-cell morphological tracking of liver cell states to identify small-molecule modulators of liver differentiation

2023-11-16

Abstract excerpt

Alternative therapeutic strategies are urgently required to treat liver disease, which is responsible for 2 million deaths anually. By combining Cell Painting, a morphological profiling assay that captures diverse cellular states, with the bi-potent HepaRG ® liver progenitor cell line, we have developed a high-throughput, single-cell technique, to track liver cell fate and map small-molecule induced changes using...

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Literature Corpus work: f5297ad5-2237-5c4d-9f36-a86085d2af23
DOI: 10.1101/2023.11.15.567184

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