Article
Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging.
Nature communications - 9 Sept 2022
Freckmann Eva C, Sandilands Emma, Cumming Erin, Neilson Matthew, Román-Fernández Alvaro, Nikolatou Konstantina, Nacke Marisa, Lannagan Tamsin R M, Hedley Ann, Strachan David, Salji Mark, Morton Jennifer P, McGarry Lynn, Leung Hing Y, Sansom Owen J, Miller Crispin J, Bryant David M
Abstract excerpt
Single cell profiling by genetic, proteomic and imaging methods has expanded the ability to identify programmes regulating distinct cell states. The 3-dimensional (3D) culture of cells or tissue fragments provides a system to study how such states contribute to multicellular morphogenesis. Whether cells plated into 3D cultures give rise to a singular phenotype or whether multiple biologically distinct phenotypes...
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