Article

Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis

2024-07-29

Abstract excerpt

<title>Abstract</title> <p>Under neuroinflammatory conditions, astrocytes acquire a reactive phenotype that drives acute inflammatory injury as well as chronic neurodegeneration. We hypothesized that astrocytic Delta-like 4 (DLL4) may interact with its receptor NOTCH1 on neighboring astrocytes to regulate astrocyte reactivity via downstream juxtacrine signaling pathways. Here we investigated the role of astrocyti...

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Literature Corpus work: eb34d32e-0ceb-5344-92a8-e72c077529d8
DOI: 10.21203/rs.3.rs-4685590/v1

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