Alternative Splicing in Multiple Myeloma is Associated with the Non-Homologous End Joining Pathway

Abstract excerpt

<title>Abstract</title> <p>Alternative splicing plays a pivotal role in tumorigenesis and proliferation. However, its pattern and pathogenic role has not been systematically analyzed in multiple myeloma or its subtypes. Alternative splicing profiles for 598 newly diagnosed myeloma patients with comprehensive genomic annotation identified primary translocations and <italic>DIS3</italic> events to have more differe...

Topics

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• Alternative Splicing
• Multiple Myeloma
• Mutation
• Phosphoproteins
• RNA Splicing
• RNA Splicing Factors
• Serine-Arginine Splicing Factors
• Spliceosomes

Identifiers and source

Literature Corpus work

f4d8809e-9060-5a94-99bf-2b4055efb2b5

DOI

10.21203/rs.3.rs-1957271/v1