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Article

Differential RNA splicing as a potentially important driver mechanism in multiple myeloma.

Haematologica - 1 Mar 2021

Bauer Michael A, Ashby Cody, Wardell Christopher, Boyle Eileen M, Ortiz Maria, Flynt Erin, Thakurta Anjan, Morgan Gareth, Walker Brian A

Abstract excerpt

Disruption of the normal splicing patterns of RNA is a major factor in the pathogenesis of a number of diseases. Increasingly research has shown the strong influence that splicing patterns can have on cancer progression. Multiple Myeloma is a molecularly heterogeneous disease classified by the presence of key translocations, gene expression profiles and mutations but the splicing patterns in MM remains largely...

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Identifiers

PMID: 32079689
DOI: 10.3324/haematol.2019.235424
PMCID: PMC7927887

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