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Article

Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore.

Molecular membrane biology - 1 Jan 2000

Gupta Jyoti, Lindsell Paul

Abstract excerpt

Point mutations within the pore region of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel have previously been shown to alter the selectivity of the channel between different anions, suggesting that part of the pore may form an anion 'selectivity filter'. However, the full extent of this selectivity filter region and the location of anion binding sites in the pore are currently...

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Source

Identifiers

PMID: 12745925
DOI: 10.1080/0968031000045824

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Extent of the selectivity filter conferred by the sixth transmembrane region in the CFTR chloride channel pore.PMID 12745925Read ↗

Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Semantic proximity Read ↗

Structural identification of a selectivity filter in CFTRSemantic proximity Read ↗

Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.Semantic proximity Read ↗

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.Semantic proximity Read ↗

Anion conductance selectivity mechanism of the CFTR chloride channel.Semantic proximity Read ↗

Novel pore-lining residues in CFTR that govern permeation and open-channel block.Semantic proximity Read ↗

Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge.Semantic proximity Read ↗

Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance.Semantic proximity Read ↗

Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore.Semantic proximity Read ↗

Functional differences in pore properties between wild-type and cysteine-less forms of the CFTR chloride channel.Semantic proximity Read ↗

Positive charges at the intracellular mouth of the pore regulate anion conduction in the CFTR chloride channel.Semantic proximity Read ↗

Identification of positive charges situated at the outer mouth of the CFTR chloride channel pore.Semantic proximity Read ↗

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