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Article

Novel pore-lining residues in CFTR that govern permeation and open-channel block.

Neuron - 1 Sept 1994

McDonough S, Davidson N, Lester H A, McCarty N A

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is both a member of the ATP-binding cassette superfamily and a Cl(-)-selective ion channel. We investigated the permeation pathway of human CFTR with measurements on conduction and open-channel blockade by diphenylamine-2-carboxylic acid (DPC). We used site-directed mutagenesis and oocyte expression to locate residues in transmembrane domain (TM) 6...

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Share to Amino Acid Sequence
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Source

Identifiers

PMID: 7522483
DOI: 10.1016/0896-6273(94)90030-2

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Novel pore-lining residues in CFTR that govern permeation and open-channel block.PMID 7522483Read ↗

Direct comparison of the functional roles played by different transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.Semantic proximity Read ↗

Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore.Semantic proximity Read ↗

Structural identification of a selectivity filter in CFTRSemantic proximity Read ↗

Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation.Semantic proximity Read ↗

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Semantic proximity Read ↗

Mutations in CFTR associated with mild-disease-form Cl- channels with altered pore properties.Semantic proximity Read ↗

Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity.Semantic proximity Read ↗

Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel.Semantic proximity Read ↗

The gating of the CFTR channel.Semantic proximity Read ↗

Modeling the Conformational Changes Underlying Channel Opening in CFTRSemantic proximity Read ↗

Conformational change of the extracellular parts of the CFTR protein during channel gating.Semantic proximity Read ↗

Electrophysiological Approaches for the Study of Ion Channel Function.Semantic proximity Read ↗

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