Article
Novel pore-lining residues in CFTR that govern permeation and open-channel block.
Neuron - 1 Sept 1994
McDonough S, Davidson N, Lester H A, McCarty N A
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) is both a member of the ATP-binding cassette superfamily and a Cl(-)-selective ion channel. We investigated the permeation pathway of human CFTR with measurements on conduction and open-channel blockade by diphenylamine-2-carboxylic acid (DPC). We used site-directed mutagenesis and oocyte expression to locate residues in transmembrane domain (TM) 6...
Topics
- Amino Acid Sequence
- Animals
- Calcium Channel Blockers
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Electric Conductivity
- Extracellular Space
- Ion Channels
- Membrane Proteins
- Models, Molecular
- Molecular Sequence Data