Article

Capturing Multi-Scale Dynamics of Aortic Valve Calcification With a Coupled Fluid–Structure and Systems Biology Model

2025-12-02

Abstract excerpt

Calcific aortic valve disease (CAVD) arises from coupled interactions between blood flow, tissue mechanics, and cellular signaling. Hemodynamic forces influence endothelial and interstitial cell behavior, while the resulting tissue remodeling alters valve motion and flow patterns. Capturing this two-way feedback requires models that integrate fluid–structure mechanics with biochemical regulation, yet such multisca...

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Literature Corpus work: f49c2ee1-7c45-548f-b60d-c50d2bb2b06f
DOI: 10.64898/2025.11.28.691136

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