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Article

APOE loss of function: A genetic shield against Alzheimer's disease.

Neuron - 3 Apr 2024

Tate Mason D, Karahan Hande, Kim Jungsu

Abstract excerpt

In this issue of Neuron, Chemparathy et al.1 provide human genetics data suggesting that APOE loss-of-function mutations may confer resistance to Alzheimer's disease (AD) without compromising longevity. These data strongly support the APOE toxic gain-of-function hypothesis for AD.

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Source

Identifiers

PMID: 38574724
DOI: 10.1016/j.neuron.2024.03.003

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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