Article

A Universal, Single-Component Multilayered Self-Assembling Protein Nanoparticle Vaccine Based on Extracellular Domains of Matrix Protein 2 Against Both Influenza A and B

2024-07-07

Abstract excerpt

The development of an effective and broadly protective influenza vaccine against circulating and emerging strains remains elusive. In this study, we evaluated single-component self-assembling protein nanoparticles (1c-SApNPs) presenting the conserved matrix protein 2 ectodomain (M2e) from influenza A and B viruses (IAV and IBV, respectively) as a universal influenza vaccine. We previously designed a tandem antigen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be1ebe75-b0ad-5430-afce-50621a872799
DOI: 10.1101/2024.07.05.602266

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Universal, Single-Component Multilayered Self-Assembling Protein Nanoparticle Vaccine Based on Extracellular Domains of Matrix Protein 2 Against Both Influenza A and BDOI 10.1101/2024.07.05.602266Read

A Single-Component Multilayered Self-Assembling Protein Nanoparticle Vaccine Based on Extracellular Domains of Matrix Protein 2 against Both Influenza A and BSemantic proximity Read

Single-component multilayered self-assembling protein nanoparticles displaying extracellular domains of matrix protein 2 as a pan-influenza A vaccineSemantic proximity Read

Single-Component Multilayered Self-Assembling Protein Nanoparticles Displaying Extracellular Domains of Matrix Protein 2 as a Pan-influenza A VaccineSemantic proximity Read

Self-Assembly M2e-Based Peptide Nanovaccine Confers Broad Protection Against Influenza VirusesSemantic proximity Read

M2e-Based Influenza Vaccines with Nucleoprotein: A ReviewSemantic proximity Read

Advances in Nanoparticle-Enhanced Vaccine Strategies: Towards a Universal Protection Against Influenza B VirusesSemantic proximity Read

A Multivalent Vaccine Based on Ferritin Nanocage Elicits Potent Protective Immune Responses against SARS-CoV-2 Mutations.Semantic proximity Read

Challenges and developments in universal vaccine design against SARS-CoV-2 variantsSemantic proximity Read

Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles to Elicit Broad Antibody ResponsesSemantic proximity Read

A human-informed multi-patch T-cell vaccine induces broad CD8⁺ immunity and protects against SARS-CoV-2 infectionSemantic proximity Read

Durable cross-protective neutralizing antibody responses elicited by lipid nanoparticle-formulated SARS-CoV-2 mRNA vaccinesSemantic proximity Read

M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challengeSemantic proximity Read