Article

CMT disease 2A and demyelination decouple ATP and ROS production by axonal mitochondria

2018-11-05

Abstract excerpt

Mitochondria are critical for the function and maintenance of myelinated axons notably through ATP production. A by-product of this activity is reactive oxygen species (ROS), which are highly deleterious for neurons. While ROS and metabolism are involved in several neurodegenerative diseases, it is still unclear how axonal activity or myelin modulates ATP and ROS production in axonal mitochondria. We imaged and qu...

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Literature Corpus work: f48320a3-db9b-539f-aea0-843806aa0a06
DOI: 10.1101/462523

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