Article

New lesion formation is associated with accelerated brain aging in multiple sclerosis

2026-08-31

Abstract excerpt

<h4>Background: </h4> Brain age is a biomarker of brain tissue integrity associated with disability in multiple sclerosis. While new lesion formation is central to MS diagnosis and treatment monitoring, its direct relationship to brain aging has not been established. <h4>Methods:</h4> We analyzed 163 people with MS with clinical and MRI assessments at baseline and years 3, 6, and 8. Brain age was estimated using B...

Identifiers and source

Literature Corpus work: f480ca4a-1587-5f26-b479-d278a7079b36
DOI: 10.64898/2026.08.27.26361556

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

New lesion formation is associated with accelerated brain aging in multiple sclerosisDOI 10.64898/2026.08.27.26361556Read

Deep grey matter volume loss drives disability worsening in multiple sclerosisSemantic proximity Read

Brain age gap correlates with DTI-derived microstructural abnormalities in multiple sclerosisSemantic proximity Read

Characterisation of MS phenotypes across the age span using a novel data set integrating 34 clinical trials (NO.MS cohort): Age is a key contributor to presentation.Semantic proximity Read

Progression of regional atrophy in the left hemisphere contributes to clinical and cognitive deterioration in multiple sclerosis: A 5-year study.Semantic proximity Read

Magnetization transfer imaging to monitor the evolution of MS: a 1-year follow-up study.Semantic proximity Read

Molecular mechanisms associated with multiple sclerosis progression, severity and phenotypeSemantic proximity Read

Confounder-adjusted MRI-based predictors of multiple sclerosis disabilitySemantic proximity Read

Progression of regional grey matter atrophy in multiple sclerosisSemantic proximity Read

The sequence of structural, functional and cognitive changes in multiple sclerosisSemantic proximity Read

Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patientsSemantic proximity Read

Multimodal predictors of disability progression and processing speed decline in relapsing-remitting multiple sclerosisSemantic proximity Read

Cortical lesion load associates with progression of disability in multiple sclerosis.Semantic proximity Read