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Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients

24 Aug 2022

Abstract excerpt

Background Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS) characterized by irreversible disability at later progressive stages. A growing body of evidence suggests that disease progression depends on age and inflammation within the CNS. We aimed to investigate epigenetic aging in bulk brain tissue and sorted nuclei from MS patients using DNA...

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PMID: 36092807
DOI: 10.3389/fnagi.2022.926468

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