Article
Characterization of the CpG Island Hypermethylated Phenotype Subclass in Primary Melanomas.
The Journal of investigative dermatology - 1 Jul 2022
Conway Kathleen, Tsai Yihsuan S, Edmiston Sharon N, Parker Joel S, Parrish Eloise A, Hao Honglin, Kuan Pei Fen, Scott Glynis A, Frank Jill S, Googe Paul, Ollila David W, Thomas Nancy E
Abstract excerpt
Cutaneous melanoma can be lethal even if detected at an early stage. Epigenetic profiling may facilitate the identification of aggressive primary melanomas with unfavorable outcomes. We performed clustering of whole-genome methylation data to identify subclasses that were then assessed for survival, clinical features, methylation patterns, and biological pathways. Among 89 cutaneous primary invasive melanomas, we...
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