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Article

Genes regulated by DNA methylation are involved in distinct phenotypes during melanoma progression and are prognostic factors for patients.

Molecular oncology - 1 May 2022

Papaiz Debora D'Angelo, Rius Flávia Eichemberger, Ayub Ana Luísa Pedroso, Origassa Clarice S, Gujar Hemant, Pessoa Diogo de Oliveira, Reis Eduardo Moraes, Nsengimana Jérémie, Newton-Bishop Julia, Mason Christopher E, Weisenberger Daniel J, Liang Gangning, Jasiulionis Miriam Galvonas

Abstract excerpt

In addition to mutations, epigenetic alterations are important contributors to malignant transformation and tumor progression. The aim of this work was to identify epigenetic events in which promoter or gene body DNA methylation induces gene expression changes that drive melanocyte malignant transformation and metastasis. We previously developed a linear mouse model of melanoma progression consisting of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35075772
DOI: 10.1002/1878-0261.13185
PMCID: PMC9067153

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