Article

Functional diversity of PFKFB3 splice variants in glioblastomas

2020-10-09

Abstract excerpt

Tumor cells tend to metabolize glucose through aerobic glycolysis instead of oxidative phosphorylation in mitochondria. One of the rate limiting enzymes of glycolysis is 6-phosphofructo-1-kinase, which is allosterically activated by fructose 2,6-bisphosphate which in turn is produced by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2 or PFKFB). Mounting evidence suggests that cancerous tissues...

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Literature Corpus work: f466e629-1bfb-5fd6-a562-5722cb0fb85d
DOI: 10.1101/2020.10.09.332817

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