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From the Incretin System to the Entero–Pancreatico–Hepatico–Systemic Polyhormonal Metabolic Homeostasis Network

2026-07-28

Abstract excerpt

The remarkable evolution of incretin-based therapeutics from selective glucagon-like peptide-1 receptor agonists to dual, triple and emerging polyagonists has fundamentally expanded our understanding of metabolic regulation. Clinical trials have consistently demonstrated coordinated improvements in glycaemic control, hepatic steatosis, body composition, insulin sensitivity, cardiovascular and renal outcomes, infla...

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Literature Corpus work
db1ef2c5-3bdc-5641-bdd1-df4b0fb100ad
DOI
10.20944/preprints202607.2008.v1
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