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Dominant Transmission of Prepubertal Gynecomastia Due to Serum Estrone Excess: Hormonal, Biochemical, and Genetic Analysis in a Large Kindred

1 Jan 2005

Abstract excerpt

Increased extraglandular aromatization has been reported to cause the rare entity of familial gynecomastia. Recently heterozygous inversions at the p450 aromatase gene promotor locus were detected in two different families with this syndrome. We studied a family in which seven affected males over three generations had inherited prepubertal gynecomastia in an autosomal dominant manner. The proband developed...

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PMID: 15483104
DOI: 10.1210/jc.2004-1566

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