Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alternative pathway androgen biosynthesis and human fetal female virilization

14 Oct 2019

Abstract excerpt

Androgen biosynthesis in the human fetus proceeds through the adrenal sex steroid precursor dehydroepiandrosterone, which is converted to testosterone in the gonads, followed by further activation to 5α-dihydrotestosterone in genital skin, thereby facilitating male external genital differentiation. Congenital adrenal hyperplasia due to P450 oxidoreductase deficiency results in disrupted dehydroepiandrosterone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Hormonal and reproductive studies
Share to Sexual Differentiation and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31611378
DOI: 10.1073/pnas.1906623116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alternative pathway androgen biosynthesis and human fetal female virilizationPMID 31611378Read ↗

Alternative pathway androgen biosynthesis and human fetal female virilizationSemantic proximity Read ↗

Alternative (backdoor) androgen production and masculinization in the human fetusSemantic proximity Read ↗

Classic and backdoor pathways of androgen biosynthesis in human sexual developmentSemantic proximity Read ↗

The “backdoor pathway” of androgen synthesis in human male sexual developmentSemantic proximity Read ↗

Prenatal diagnosis of congenital adrenal hyperplasia caused by P450 oxidoreductase deficiency.Semantic proximity Read ↗

Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation.Semantic proximity Read ↗

46,XX DSD due to Androgen Excess in Monogenic Disorders of Steroidogenesis: Genetic, Biochemical, and Clinical FeaturesSemantic proximity Read ↗

Backdoor pathway for dihydrotestosterone biosynthesis: Implications for normal and abnormal human sex developmentSemantic proximity Read ↗

Mutation of HSD3B2 Gene and Fate of Dehydroepiandrosterone.Semantic proximity Read ↗

Severe Hyperandrogenism in 46,XX Congenital Adrenal Hyperplasia: Molecular Physiopathology, Late Diagnoses, and Personalized Management.Semantic proximity Read ↗

Non-Virilizing Congenital Adrenal Hyperplasia in a Female Patient with a Novel HSD3B2 Mutation.Semantic proximity Read ↗

Rare forms of genetic steroidogenic defects affecting the gonads and adrenals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.