Article

Alternative pathway androgen biosynthesis and human fetal female virilization

2019-04-15

Abstract excerpt

<h4>ABSTRACT</h4> Androgen biosynthesis in the human fetus proceeds through the adrenal sex steroid precursor dehydroepiandrosterone, which is converted towards testosterone in the gonads, followed by further activation to 5α-dihydrotestosterone in genital skin, thereby facilitating male external genital differentiation. Congenital adrenal hyperplasia due to P450 oxidoreductase deficiency results in disrupted deh...

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Literature Corpus work: 29d12b2f-0650-5516-a040-c46d453dba24
DOI: 10.1101/609289

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