Article

Rapid evolution of bacterial AB5 toxin B subunits independent of A subunits: sialic acid binding preferences correlate with host range and toxicity

2021-05-28

Abstract excerpt

Cytotoxic A subunits of bacterial AB 5 toxins enter the cytosol following B subunit binding to host cell glycans. We report that A subunit phylogeny evolves independently of B subunits and suggest a future B subunit nomenclature based on species name. Phylogenetic analysis of B subunits that bind sialic acids (Sias) with homologous molecules in databases also show poor correlation with phylogeny. These data indic...

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Literature Corpus work: d22de803-3ea8-5eea-a262-44a9ce7eb06e
DOI: 10.1101/2021.05.28.446168

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