Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53

Abstract excerpt

Ubiquitin-specific proteases (USPs) are the largest class of human deubiquitinases (DUBs) and comprise its phylogenetically most distant members USP53 and USP54, which are annotated as catalytically inactive pseudo-enzymes. Conspicuously, mutations in the USP domain of USP53 cause familial intrahepatic cholestasis. Here we report the discovery that USP53 and USP54 are in fact active DUBs with high specificity for...

Topics

Open a Topic to create a Post that cites this publication.

• Autophagy in Disease and Therapy
• Biomarkers, Tumor
• Cancer-related Molecular Pathways
• Cholestasis
• Molecular Targeted Therapy
• Mutation
• Neoplasms
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

f3f4412e-0966-51b4-a7b8-ead6f064e37f

DOI

10.1101/2024.07.07.602376