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Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis

8 Jun 2020

Abstract excerpt

Because of the ongoing pandemic around the world, the mechanisms underlying the SARS-CoV-2-induced COVID-19 are subject to intense investigation. Based on available data for the SARS-CoV-1 virus, we suggest how CoV-2 localization of RNA transcripts in mitochondria hijacks the host cell's mitochondrial function to viral advantage. Besides viral RNA transcripts, RNA also localizes to mitochondria. SARS-CoV-2 may...

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PMID: 32510973
DOI: 10.1152/ajpcell.00224.2020

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