Back to search

Article

Diethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cells

2025-09-08

Abstract excerpt

<title>Abstract</title> <p> Diethylcarbamazine is a classic anthelmintic that is used for the prevention and treatment of lymphatic filariasis. The mode of action of diethylcarbamazine is still not well understood with the consensus that it acts on the host immune system, rather than directly acting on the adult parasite. Recent studies, have found that diethylcarbamazine acts on the muscle of adult female <ita...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f39bdd49-5d1f-58e0-9cee-6fd820c2d671
DOI
10.21203/rs.3.rs-7359086/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Diethylcarbamazine elicits calcium signals by activation of Brugia malayi TRP-2b channels heterologously expressed in HEK293 cellsDOI 10.21203/rs.3.rs-7359086/v1
Pharmacological profiling of a <i>Brugia malayi</i> muscarinic acetylcholine receptor as a putative antiparasitic targetSemantic proximity
Bma-LAD-2, an intestinal cell adhesion protein, as a potential therapeutic target for lymphatic filariasisSemantic proximity
Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channelSemantic proximity
β-alanine betaine and nAChRs in <i>Ascaris</i>Semantic proximity
Functional investigation of conserved glutamate receptor subunits reveals a new mode of action of macrocyclic lactones in nematodesSemantic proximity
Acetylcholinesterase and Nicotinic Acetylcholine Receptors in Schistosomes and Other Parasitic HelminthsSemantic proximity
An In Vitro/In Vivo Model to Analyze the Effects of Flubendazole Exposure on Adult Female Brugia malayiSemantic proximity
Meroterpenoid Chrodrimanins Are Selective and Potent Blockers of Insect GABA-Gated Chloride Channels.Semantic proximity
Positive allosteric modulation of emodepside sensitive <i>Brugia malayi</i> SLO-1F and <i>Onchocerca volvulus</i> SLO-1A potassium channels by GoSlo-SR-5-69Semantic proximity
The Nervous Systems of Helminths as Targets for DrugsSemantic proximity
Effects of Emodepside on Single-Channel Properties of Onchocerca volvulus SLO-1A (BK) Potassium ChannelsSemantic proximity
Select a neighboring publication to make it the new centre.