Article

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1 transcription signature

2023-11-20

Abstract excerpt

<h4>Summary</h4> A G4C2 repeat expansion in the gene C9orf72 (C9) is the most common genetic cause of sporadic and familial frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). What determines why cell death is triggered only in specific neuronal populations, while others remain ‘protected’ or are less susceptible to disease is still an open question. In particular, whether it is the transcript...

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Literature Corpus work: f388de81-75e9-5465-9988-a3270a311dab
DOI: 10.1101/2023.11.20.567861

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