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Article

The C9ORF72 repeat expansion alters neurodevelopment.

Cell reports - 29 Aug 2023

Hendricks Eric, Quihuis Alicia M, Hung Shu-Ting, Chang Jonathan, Dorjsuren Nomongo, Der Balint, Staats Kim A, Shi Yingxiao, Sta Maria Naomi S, Jacobs Russell E, Ichida Justin K

Abstract excerpt

Genetic mutations that cause adult-onset neurodegenerative diseases are often expressed during embryonic stages, but it is unclear whether they alter neurodevelopment and how this might influence disease onset. Here, we show that the most common cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), a repeat expansion in C9ORF72, restricts neural stem cell proliferation and reduces...

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Identifiers

PMID: 37590144
DOI: 10.1016/j.celrep.2023.112983
PMCID: PMC10757587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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