Article

Glial cell-intrinsic and non-cell autonomous toxicity in a Drosophila C9orf72 neurodegeneration model

2025-10-07

Abstract excerpt

The most common genetic cause of both familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G 4 C 2 repeat in the first intron of the gene C9orf72. The C9orf72 repeat expansion is bidirectionally transcribed into sense and anti-sense RNA foci, and also produces dipeptide repeats (DPRs) via a non-canonical translation mechanism known as repeat-associated (RAN) translation....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f465c29-b492-545a-ad71-e02fe4fce803
DOI: 10.1101/2025.10.07.680869

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glial cell-intrinsic and non-cell autonomous toxicity in a Drosophila C9orf72 neurodegeneration modelDOI 10.1101/2025.10.07.680869Read

<i>C9orf72</i> repeat expansions cause neurodegeneration in <i>Drosophila</i> through arginine-rich proteinsSemantic proximity Read

Divergent Molecular Pathways for Toxicity of Selected Mutant C9ORF72-derived Dipeptide RepeatsSemantic proximity Read

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In VivoSemantic proximity Read

Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTDSemantic proximity Read

LINE-1 replication in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and non-cell autonomous programmed cell deathSemantic proximity Read

C9orf72 Dipeptide Repeats Cause Selective Neurodegeneration and Cell-Autonomous Excitotoxicity in Drosophila Glutamatergic NeuronsSemantic proximity Read

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegenerationSemantic proximity Read

Retrotransposon Activation Contributes to Neurodegeneration in a <i>Drosophila</i> TDP-43 Model of ALSSemantic proximity Read

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport.Semantic proximity Read

<i>C9orf72</i> -associated G4C2 hexanucleotide repeat expression in <i>Drosophila</i> mushroom bodies causes age dependent TDP-43 pathology and dementia relevant phenotypes mediated in part by the glypican Dlp/GPC6Semantic proximity Read

Differential neuronal vulnerability to C9orf72 repeat expansion driven by Xbp1 transcription signatureSemantic proximity Read

The Gypsy Endogenous Retrovirus Drives Non-Cell-Autonomous Propagation in a Drosophila TDP-43 Model of NeurodegenerationSemantic proximity Read