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Article

Treatment Effect Estimates in Randomised Trials With Ai-augmented Control Arms

2025-12-16

Abstract excerpt

<title>Abstract</title> <p>This study empirically illustrates the risk of errors and misleading conclusions associated with trial augmentation with controls generated by AI using solely trial data. We generated 8,000,000 trials with AI-augmented control arms using the data from two large trials (IST and IST3), removed a fraction of the original control arm and replaced it with generated data with algorithms train...

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Literature Corpus work
f3694e14-3883-5f92-8408-46c3188b662b
DOI
10.21203/rs.3.rs-8223779/v1
Open publication

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Treatment Effect Estimates in Randomised Trials With Ai-augmented Control ArmsDOI 10.21203/rs.3.rs-8223779/v1
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