Article

RCT-Twin-GAN Generates Digital Twins of Randomized Control Trials Adapted to Real-world Patients to Enhance their Inference and Application

2023-12-08

Abstract excerpt

<h4>Background</h4> Randomized clinical trials (RCTs) are designed to produce evidence in selected populations. Assessing their effects in the real-world is essential to change medical practice, however, key populations are historically underrepresented in the RCTs. We define an approach to simulate RCT-based effects in real-world settings using RCT digital twins reflecting the covariate patterns in an electronic...

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Literature Corpus work: ee69d209-650c-57d3-848a-13e1c2f3b571
DOI: 10.1101/2023.12.06.23299464

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