Randomized trials of ‘personalized’, ‘individualized’ and ‘precision’ interventions are very diverse and have low transparency and high bias

Abstract excerpt

<h4>Background and objective</h4> The terms ‘personalized’, individualized’ and ‘precision’ are increasingly used to describe interventions, yet their operational meaning is often unclear. Despite extensive conceptual debate, no empirical work has examined how these terms are applied in randomized controlled trials (RCTs) and how transparent and reliable the results of these trials are. <h4>Methods</h4> We surve...

Topics

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• Cell- and Tissue-Based Therapy
• Cystic Fibrosis
• Cystic Fibrosis Transmembrane Conductance Regulator
• Evidence-Based Medicine
• Information Storage and Retrieval
• Mutation
• Precision Medicine
• Randomized Controlled Trials as Topic

Identifiers and source

Literature Corpus work

57e928ee-5668-5374-8076-03dbb7cd8d9e

DOI

10.64898/2026.02.09.26345904