Article

Mitochondrial Iron Handling and Lipid Peroxidation as Drivers of Ferroptosis

2026-02-05

Abstract excerpt

Mitochondria are a key organelle in maintaining metabolic homeostasis. It not only generates most of the cell's energy through oxidative phosphorylation but also acts as a complex sensor of the redox state and oxygen in the cell. This review thoroughly ana-lyzes the interactions among mitochondrial iron metabolism, mitochondrial reactive oxygen species (mtROS), and lipid peroxidation (LPO), the triggering factors...

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Literature Corpus work: 39bec977-7eae-525c-979d-dae09b1ad213
DOI: 10.20944/preprints202602.0439.v1

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