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Mitochondrial regulation of ferroptosis

30 Jul 2021

Abstract excerpt

Ferroptosis is a form of iron-dependent regulated cell death driven by uncontrolled lipid peroxidation. Mitochondria are double-membrane organelles that have essential roles in energy production, cellular metabolism, and cell death regulation. However, their role in ferroptosis has been unclear and somewhat controversial. In this Perspective, I summarize the diverse metabolic processes in mitochondria that...

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PMID: 34328510
DOI: 10.1083/jcb.202105043

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