Article

Comprehensive In Silico Functional Characterization of TP53 Variants Using an Automated Web-Based Annotation Platform

2026-02-24

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> TP53 is one of the most frequently mutated tumor suppressor genes in human cancers, with mutations occurring in approximately 50% of all malignancies and exceeding 90% in certain subtypes such as high-grade serous ovarian carcinoma. Accurate interpretation of TP53 variants remains essential for both research and clinical diagnostics; however, manual mutation i...

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Literature Corpus work: f345c007-f706-541c-8b10-ca26aa1d5351
DOI: 10.21203/rs.3.rs-8914143/v1

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