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Seshat: A Web service for accurate annotation, validation, and analysis of TP53 variants generated by conventional and next-generation sequencing.

Human mutation - 1 Jul 2018

Tikkanen Tuomas, Leroy Bernard, Fournier Jean Louis, Risques Rosa Ana, Malcikova Jitka, Soussi Thierry

Abstract excerpt

Accurate annotation of genomic variants in human diseases is essential to allow personalized medicine. Assessment of somatic and germline TP53 alterations has now reached the clinic and is required in several circumstances such as the identification of the most effective cancer therapy for patients with chronic lymphocytic leukemia (CLL). Here, we present Seshat, a Web service for annotating TP53 information...

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PMID: 29696732
DOI: 10.1002/humu.23543

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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